A medication called Othera 20mg Tablet lowers the quantity of acid your stomach produces. It is used to treat peptic ulcer disease, acid reflux, and other issues with your food pipe.
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Othera 20mg Tablet should be used during pregnancy only if considered clearly necessary. Consult your doctor before taking Othera 20mg Tablet.
Othera 20mg Tablet is not recommended for use in breastfeeding women as it is unclear whether it passes through the breast milk. Consult your doctor before taking Othera 20mg Tablet.
Othera 20mg Tablet is not recommended for use in breastfeeding women as it is unclear whether it passes through the breast milk. Consult your doctor before taking Othera 20mg Tablet.
In some cases, Othera 20mg Tablet may cause dizziness, sleep, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.
Othera 20mg Tablet should be used with caution in patients with severe kidney problems. Consult your doctor before taking Othera 20mg Tablet.
Othera 20mg Tablet should be used with caution in patients with severe liver problems. Consult your doctor before taking Othera 20mg Tablet.
Othera 20mg Tablet is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of enzymes in the stomach cell. It hence reduces gastric acidity by blocking the final step in acid production and helps in the relief of acid-related indigestion and heartburn.
Esomeprazole is used to treat:
Esomeprazole, the active ingredient in Othera 20mg Tablet, works by preventing the final step of gastric acid production. It achieves this by binding covalently to the cysteine sulfhydryl group in the H+/K+ ATPase enzyme on the secretory surface of gastric parietal cells. This binding inhibits the production of gastric acid.
The inhibitory effect of esomeprazole on gastric acid secretion is not dependent on the specific stimulus. It effectively reduces both basal and stimulated acid secretion. Since the binding of esomeprazole to the H+/K+ ATPase enzyme is irreversible, new enzymes need to be synthesized to restore acid secretion. This means that the antisecretory effect of esomeprazole lasts for more than 24 hours.
In summary, esomeprazole acts by irreversibly binding to the H+/K+ ATPase enzyme, resulting in a long-lasting inhibition of gastric acid secretion.
Adult Dose:
Elderly: No dosage adjustment is needed.
Hepatic Impairment:
Child Dose:
Renal Dose: No dosage adjustment is needed for renal impairment.
Take Othera 20mg Tablet as advised by your doctor. It can be taken with or without food. Swallow Othera 20mg Tablet with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Othera 20mg Tablet can potentially interact with various medications, including blood thinners (such as clopidogrel and warfarin), antifungal drugs (like ketoconazole, voriconazole, itraconazole, and posaconazole), certain anti-HIV medications (atazanavir, nelfinavir, and rilpivirine), specific antiviral drugs (nelfinavir), iron supplements, antibiotics (ampicillin and rifampicin), heart medication (digoxin), and anti-cancer drug (methotrexate). It is important to inform your doctor if you are taking any of these medications.
It is also essential to note that Othera 20mg Tablet can interact with St. John's wort, an herbal plant used as an antidepressant. Taking St. John's wort alongside Othera 20mg Tablet may affect the efficacy of the medication. Therefore, it is advised to avoid using St. John's wort while taking Othera 20mg Tablet.
Patients with Clostridium difficile-associated diarrhea, magnesium, and vitamin B12 deficiency (increasing the risk of bone fractures), atrophic gastritis (inflammation of the stomach lining), and acute interstitial nephritis (inflammation of kidney cells) should not be given Othera 20mg Tablet.
Esomeprazole should not be used in patients who have a known hypersensitivity or allergy to any component of the formulation or to substituted Benzimidazoles. It is contraindicated in such individuals.
Pregnancy: There have been no adequate and well-controlled studies conducted on pregnant women with esomeprazole. However, it is important to note that esomeprazole is the S-isomer of omeprazole. Available epidemiological data regarding omeprazole use during the first trimester of pregnancy have not shown an increased risk of major congenital malformations or other adverse pregnancy outcomes. Animal reproduction studies in rats and rabbits have shown dose-dependent embryo-lethality at omeprazole doses that were approximately 3.4 to 34 times higher than the recommended human dose of 40 mg, based on body surface area for a 60 kg person.
Lactation: Esomeprazole is the S-isomer of omeprazole, and limited data suggest that omeprazole may be present in human milk. There is currently no clinical data available on the effects of esomeprazole on breastfed infants or on milk production. When considering the use of esomeprazole in breastfeeding mothers, it is important to weigh the developmental and health benefits of breastfeeding against the mother's clinical need for therapy and any potential adverse effects on the breastfed infant, either from the treatment itself or from the underlying maternal condition.
It is important to avoid taking Othera 20mg Tablet in the following situations:
Othera 20mg Tablet may also interact with certain medications. It is important to inform your doctor if you are taking any of the following medications:
Prolonged use of Othera 20mg Tablet may lead to complications such as lupus erythematosus (an inflammatory condition where the immune system attacks its own tissues), and deficiency of vitamin B12 and magnesium. It is important to be aware of these potential risks.
Additionally, Othera 20mg Tablet may mask the symptoms of gastric cancer. If you experience severe stomach pain or gastric bleeding (blood in mucous or stool), it is important to consult your doctor immediately.
Store in a cool & dry place below 25ºC, and protect from light. Keep out of reach of children.
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